Molecular Docking of Gallic Acid and Its Derivatives as the Potential nNOS Inhibitors

The global prevalence of anxiety and depression rates have increased by 25% due to the impact COVID-19 pandemic. Depression can occur an increase in NO produced nNOS enzyme. Gallic acid its derivatives be obtained from nature various biological activities. This study aimed determine potential gallic as inhibitors using molecular docking method with parameters binding energy values, RMSD specific amino residues. results showed that acid, 4-O-methyl epigallocatechin gallate had bond energies −1.87; −2.36; −0.12 kcal/mol, respectively. Compared standard ligand, which −2.84 4-O-(6-galloyl glucoside) −4.12 kcal/mol. Based on these results, potentially inhibit nNOS.